A Human Multi-Organ Tissue Equivalent Platform to Model High Consequence Threat Agents Tender

Procurement Summary

Country : USA

Summary : A Human Multi-Organ Tissue Equivalent Platform to Model High Consequence Threat Agents

Deadline : 14 Apr 2025

Other Information

Notice Type : Tender

TOT Ref.No.: 116731910

Document Ref. No. : HT942525R0053

Competition : ICB

Financier : Self Financed

Purchaser Ownership : Public

Tender Value : Refer Document

Purchaser's Detail

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Tender Details

Description

The United States Army Medical Research Acquisition Activity (USAMRAA) intends to issue a Firm Fixed Price sole source contract under the authority of FAR 6.302-1 (a) (2) - Only One Responsible Source and No Other Services will Satisfy Agency Requirements to Wake Forest Institute for Regenerative Medicine (WFIRM), Winston-Salem, NC, on behalf of the United States Army Medical Research of Infectious Diseases (USAMRIID).

The Government has a requirement for the development of a micro engineered human organ/tissue equivalent platform for modeling the pathogenic outcomes of emerging infectious diseases and test the efficacy of medical countermeasures (MCMs). The scope of effort will encompass the task of protecting the warfighter from a natural or manmade attack and have the ability to rapidly identify the best methods available to maintain mission critical status. The Contractor will conduct all activities in compliance with FDA CVM regulations, current Good Manufacturing Processes (cGMP), and other applicable regulations as necessary. The Government seeks an Organ Tissue Equivalent (OTE) platform, which utilizes cutting edge 3D organ-on-a-chip technologies and offers one such solution for the military by providing a tool for rapidly identifying medical countermeasures for the prevention and treatment of emerging viral diseases. The lung OTE shall be comprised entirely of human cells including the epithelial, endothelial, stromal, and inflammatory components of native lung tissue. Unlike typical 2D systems, these constructs shall be arranged in a pseudostratified architecture and produce mucus and surfactant providing a physiologically relevant model system. The overarching goal of the proposed studies is to validate the human lung construct as a flexible model for viral pulmonary infections and the resultant inflammatory response. The system will also be used to test the efficacy of potential medical countermeasures, and for identifying potential d...
Active Contract Opportunity
Notice ID : HT942525R0053
Related Notice
Department/Ind. Agency : DEPT OF DEFENSE
Sub-tier : DEFENSE HEALTH AGENCY (DHA)
Office: ARMY MED RES ACQ ACTIVITY
General Information
Contract Opportunity Type: Special Notice (Original)
Original Published Date: Mar 24, 2025 04:12 pm EDT
Original Response Date: Apr 14, 2025 10:00 am EDT
Inactive Policy: 15 days after response date
Original Inactive Date: Apr 29, 2025
Initiative: None

Classification
Original Set Aside:
Product Service Code: AJ13 - GENERAL SCIENCE & TECHNOLOGY R&D SVCS; GENERAL SCIENCE & TECHNOLOGY; ExPERIMENTAL DEVELOPMENT
NAICS Code: 621511 - Medical Laboratories

Place of Performance: MD USA

Documents

 Tender Notice