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COMMERCE, DEPARTMENT OF | NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY has floated a tender for Confocal Microscope System - Sources Sought Notice. The project location is USA and the tender is closing on 03 Dec 2024. The tender notice number is NIST-SS25-CHIPS-0029, while the TOT Ref Number is 110387012. Bidders can have further information about the Tender and can request the complete Tender document by Registering on the site.
Procurement Summary
Country : USA
Summary : Confocal Microscope System - Sources Sought Notice
Deadline : 03 Dec 2024
Other Information
Notice Type : Tender
TOT Ref.No.: 110387012
Document Ref. No. : NIST-SS25-CHIPS-0029
Competition : ICB
Financier : Self Financed
Purchaser Ownership : Public
Tender Value : Refer Document
Purchaser's Detail
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Login to see detailsTender Details
Description
The purpose of this sources sought notice is to conduct market research and identify potential sources of commercial products/services that satisfy the Government-s anticipated needs.
BACKGROUND
The National Institute of Standards and Technology (NIST), specifically the Biomedical Measurement Technologies group, is seeking an automated high-speed and high-resolution confocal scanning microscope. This microscope will be used for imaging biomolecules, such as proteins, DNA, and biological cells, on various substrates including quartz, silicon, and standard microscope slides.
The project aims to assess the surface coverage of fluorescently tagged biomolecules by measuring the total fluorescence in each field of view. In many cases, high spatial resolution (approaching 100 nm) is desired for these measurements to study localization on nanostructures on the substrate and will be accomplished by utilizing confocal microscopy. Since the focus is on molecules that are tagged, rather than cells that typically contain a high density of fluorophores, the signal-to-noise ratio (SNR) is critical for both confocal and widefield imaging. For confocal imaging this might be achievable by hardware and software capabilities that allow operating at higher effective pinhole sizes quantified by the light collection efficiency in Airy Units (AU), e.g., achieving the resolution of 0.3 AU confocal image with the SNR of a 1.2 AU pinhole. For widefield imaging the requirement for maximizing SNR might translate into using cameras with quantum efficiencies (QE) of 90 % or above. Additionally, it is essential to monitor the coverage of the receptors on the surface and their change over time, necessitating instrumentation with exceptional stability and the capability to track drift in focus and other instrument parameters.
The microscope must fulfill a wide range of requirements as outlined above, supporting various imaging modalities such as brightfield imaging, w...
Active Contract Opportunity
Notice ID : NIST-SS25-CHIPS-0029
Related Notice
Department/Ind. Agency : COMMERCE, DEPARTMENT OF
Sub-tier : NATIONAL INSTITUTE OF STANDARDS AND TECHNOLOGY
Office: DEPT OF COMMERCE NIST
General Information
Contract Opportunity Type: Sources Sought (Updated)
Updated Published Date: Nov 19, 2024 03:43 pm EST
Original Published Date: Nov 19, 2024 03:21 pm EST
Updated Response Date: Dec 03, 2024 03:30 pm EST
Original Response Date: Dec 03, 2024 03:30 pm EST
Inactive Policy: 15 days after response date
Updated Inactive Date: Dec 18, 2024
Original Inactive Date: Dec 18, 2024
Initiative: None
Classification
Original Set Aside:
Product Service Code: 6640 - LABORATORY EQUIPMENT AND SUPPLIES
NAICS Code: 334516 - Analytical Laboratory Instrument Manufacturing
Place of Performance: Gaithersburg, MD 20899 USA
Documents
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