Gene Targeting Vector Services Tender, USA - 86139923

Procurement Summary

Country : USA

Summary : Gene Targeting Vector Services

Deadline : 31 Jul 2023

Other Information

Notice Type : Tender

TOT Ref.No.: 86139923

Document Ref. No. : NOI-RML-2178899

Financier : Self Financed

Purchaser Ownership : Public

Tender Value : Refer Document

Purchaser's Detail

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Tender Details

Description

This is a Notice of Intent, not a request for proposal. The National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health (NIH) intends to negotiate on an other than full and open competition basis with OZGENE PTY LTD for the following services:



Gene targeting vector services to be used to investigate biologically relevant functions of JAK1 during defective mucosal immunity to C. albincans in STAT1 GOF

J&A: The National Institute of Allergy and Infectious Diseases (NIAID) Fungal Pathogenesis Section (FPS) research is broadly focused on characterization of immune response against debilitating fungal infections with an aim to improve patient outcomes via identifying at-risk patient population for early prophylaxis and uncover novel molecules that will aid in development of new immunotherapeutic modalities. This project is focused on understanding the pathophysiological mechanisms of STAT1 GOF mutations associated with defective mucosal immunity to C. albicans. This project has important implications in the medical mycology and mucosal immunology fields for: i) the possible development of novel therapeutic strategies based on the understanding of the pathophysiology mechanisms of STAT1 GOF mutations in mice; ii) the discovery of novel biomarkers for diagnostics; iii) better genetic counselling; and iv) better follow-up and outcomes of the patients. A strong motivation to establish this mouse model through Ozgene-s gene targeting vector services is for the generation of a conditional knockout mouse that allows a temporally and spatially controlled Jak1 gene expression in somatic tissues. This is as a follow-on to projects and studies previously conducted by Ozgene Pty Ltd in the scope of a larger project.



The statutory authority for this sole source requirement is 41 U.S.C. 1901 (a) (1) as implemented by FAR 13.106-1 only one responsible source and no other supply of service will satisfy agency ...
Active Contract Opportunity
Notice ID : NOI-RML-2178899
Related Notice
Department/Ind. Agency : HEALTH AND HUMAN SERVICES, DEPARTMENT OF
Sub-tier : NATIONAL INSTITUTES OF HEALTH
Office : NATIONAL INSTITUTES OF HEALTH NIAID
General Information
Contract Opportunity Type: Presolicitation (Original)
All Dates/Times are: (UTC-06:00) MOUNTAIN STANDARD TIME, DENVER, USA
Original Published Date: Jul 21, 2023 05:19 pm MDT
Original Response Date: Jul 31, 2023 01:00 pm MDT
Inactive Policy: 15 days after response date
Original Inactive Date: Aug 15, 2023
Initiative: None

Classification
Original Set Aside:
Product Service Code: Q301 - MEDICAL- LABORATORY TESTING
NAICS Code: 541380 - Testing Laboratories and Services

Place of Performance: Bethesda, MD 20814 USA

Documents

 Tender Notice