“Optimization of Aotus nancymaae non-human primate model for the development of... Tender

Procurement Summary

Country : USA

Summary : “Optimization of Aotus nancymaae non-human primate model for the development of multivalent Dengue vaccines using a self-amplifying RNA platform”.

Deadline : 17 Mar 2025

Other Information

Notice Type : Tender

TOT Ref.No.: 115697181

Document Ref. No. : 1301227990

Competition : ICB

Financier : Self Financed

Purchaser Ownership : Public

Tender Value : Refer Document

Purchaser's Detail

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Tender Details

Description

The contractor will provide general classes of services including (but not limited to) project management, design and down selection of antigens for Dengue virus (DENV) vaccine, immunogenicity testing in a mice model, laboratory testing, shipment of samples (if needed), data analysis and reporting.Monitoring activities will be conducted by NAMRU SOUTH and periodical monitoring visits and reports will be coordinated. Frequent communications such as monthly teleconferences are expected during the conduction of the study.The following elements are required:a. ANTIGEN DESIGNA.1. LABORATORY ACTIVITIESa.1.1. Antigen Design & Synthesisa.1.2. RNA Manufacturing & Releasea.1.3. In vitro antigen characterizationb. EQUIPMENT, SUPPLIES AND MATERIALS• The contractor will cover the costs of supplies and laboratory materials necessary for sample collection, transport, storage, and those for identification of novel antigens. The contractor shall provide the final vaccine candidates to NAMRU SOUTH to be tested for immunogenicity in the Aotus model.c. SHIPMENTS• The contractor shall perform shipments to NAMRU-SOUTH Lima facilities upon coordination with the NAMRU-SOUTH Parasitology. The delivery address is:Parasitology - NAMRU-SOUTHAv. Venezuela cd 36 S/N - Bellavista - Callao• The Contractor shall include the following into the shipments of samples:a. DENV vaccine candidates.b. Mice samples for further immunogenicity studies if needed.c. Any additional reagents to support Aotus vaccination procedures.d. DELIVERABLESThe materials and services specifically listed and requested must be delivered in a timely manner and must be of good quality for pre-clinical administration.• Immunogenicity studies performed in mice model.• A minimum of 8 DENV vaccine candidates to test on the Aotus model.• Enough quantity of vaccines expressed in micrograms per dose for testing immunogenicity in Aotus model.• Sequence description of the vaccine candidates.•e. SPECIAL REQUIREMENTS: Af. TA...
Active Contract Opportunity
Notice ID : 1301227990
Related Notice
Department/Ind. Agency : DEPT OF DEFENSE
Sub-tier : DEPT OF THE NAVY
Major Command : NAVSUP
Sub Command : NAVSUP OTHER HCA
Sub Command 2 : BUMED
Sub Command 3 : NAVY MEDICINE WEST
Office : NAVAL MEDICAL RESEARCH CENTER
General Information
Contract Opportunity Type: Solicitation (Original)
Original Published Date: Mar 03, 2025 09:26 am EST
Original Date Offers Due: Mar 17, 2025 12:00 pm EDT
Inactive Policy: 15 days after date offers due
Original Inactive Date: Apr 01, 2025
Initiative: None

Classification
Original Set Aside:
Product Service Code: AN14 - HEALTH R&D SERVICES; HEALTH CARE SERVICES; R&D ADMINISTRATIVE ExPENSES
NAICS Code: 54171 - Research and Development in the Physical, Engineering, and Life Sciences

Place of Performance: PER

Documents

 Tender Notice