Research Assistance Services Intent to Sole Source Dominican University of California... Tender

Procurement Summary

Country : USA

Summary : Research Assistance Services Intent to Sole Source Dominican University of California Resistant Selection for Antimalarial Drugs

Deadline : 16 May 2023

Other Information

Notice Type : Tender

TOT Ref.No.: 82433679

Document Ref. No. : 36C24E23Q0116

Financier : Self Financed

Purchaser Ownership : Public

Tender Value : Refer Document

Purchaser's Detail

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Tender Details

Description

The Veteran s Administration (VA) Office of Research and Development, Regional Procurement Office East in Pittsburgh, PA intends to negotiate on a sole source basis with Dominical University of California (DUC) in San Francisco, CA on behalf of the Portland VA Medical Center in Portland, OR. The requirement is to provide research assistance for planned VA medical studies. The planned studies focus on investigating the propensity for drug resistance in Plasmodium parasites with selected synergistic acridone lead candidate(s) and to identify the molecular target(s) through whole genome sequencing and analysis.The specific work to be performed includes:Continuous in vitro cultivation of P. falciparum parasite strain Dd2. Continuous in vitro cultivation of P. falciparum parasite strain 106-1. Continuous in vitro cultivation of P. falciparum parasite strain HB3. Applying drug pressure (T16.5) to culture of P. falciparum parasite strain Dd2 and continuously monitor the growth of the parasites. Applying drug pressure (T16.5) to culture of P. falciparum parasite strain 106-1 and continuously monitor the growth of the parasites. Applying drug pressure (T16.5) to culture of P. falciparum parasite strain HB3 and continuously monitor the growth of the parasites. Performing susceptibility assays to T16.5 (with standard 72 hour growth inhibition assays using Sybr Green detection) and compare with the drug-free controls, when stable changes in phenotype results in a parasite culture (the ability of parasites to grow similar to drug-free controls in the presence of T16.5).Testing a panel of T16.5 related acridones, and non-related standard antimalarials currently in use (chloroquine, piperaquine, lumefantrine, atovaquone, dihydroartemisinin, mefloquine, pyronardine, monodesethylamodiaquine) for cross-resistance to T16.5. Cloning (for genetic purity) and cryopreserving any resistant parasites derived. Reporting drug susceptibility data, cross resistance data, parasit...
Active Contract Opportunity
Notice ID : 36C24E23Q0116
Related Notice
Department/Ind. Agency : VETERANS AFFAIRS, DEPARTMENT OF
Sub-tier : VETERANS AFFAIRS, DEPARTMENT OF
Office : RPO EAST (36C24E)
General Information
Contract Opportunity Type: Special Notice (Original)
All Dates/Times are: (UTC-04:00) EASTERN STANDARD TIME, NEW YORK, USA
Original Published Date: May 01, 2023 02:58 pm EDT
Original Response Date:
Inactive Policy: Manual
Original Inactive Date: May 16, 2023
Initiative: None

Classification
Original Set Aside:
Product Service Code: Q301 - MEDICAL- LABORATORY TESTING
NAICS Code: 541380 - Testing Laboratories and Services

Place of Performance:

Documents

 Tender Notice

36C24E23Q0116.docx