Role Of T-Cells In Hiv Cns Reservoir Seeding, Persistence, And Neuropathogenesis... Tender

Procurement Summary

Country : USA

Summary : Role Of T-Cells In Hiv Cns Reservoir Seeding, Persistence, And Neuropathogenesis (R21 Clinical Trial Not Allowed)

Deadline : 18 Mar 2025

Other Information

Notice Type : Tender

TOT Ref.No.: 110536420

Document Ref. No. : RFA-MH-26-111

Competition : ICB

Financier : Self Financed

Purchaser Ownership : Public

Tender Value : Refer Document

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Tender Details

Eradicating Latent Reservoirs Of Hiv-1 Within The Body And Achieving A Sterilizing Or Functional Cure Have Become Priority Areas In The Aids Field And Nih Aids Programs Across Many Institutes And Centers, Including Nimh. In Addition Understanding The Mechanisms Of Hiv- Associated Co-Morbidities In The Setting Of Effective Anti-Retroviral Therapy (Art) Is A Major Topic Of Interest In The Field. Hiv Associated Cns (Central Nervous System) Co-Morbidities Continue To Exist Despite Excellent Virologic Control In This Compartment. Hiv Persistence And Neuroinflammation Also Continues To Observed In The Cns In The Setting Of Art. Hiv Targets The Cns Early In Infection, And Hiv-Infected Individuals Suffer From Mild Forms Of Neurological Impairments Even Under Antiretroviral Therapy (Art). Cd4+ T Cells And Monocytes Mediate Hiv Entry Into The Brain And Constitute A Source For Hiv Persistence And Neuronal Damage. Cd8+ T Cells Are Also Massively Recruited In The Cns In Acute Infection To Control Viral Replication.
Opportunity Category : Discretionary
Opportunity Category Explanation :
Funding Instrument Type : Grant
Category of Funding Activity : EducationHealth
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Posted Date : Nov 21, 2024
Last Updated Date : Nov 21, 2024

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