TECHNOLOGY/BUSINESS OPPORTUNITY Automated High Throughput Screening Platform Tender

Procurement Summary

Country : USA

Summary : TECHNOLOGY/BUSINESS OPPORTUNITY Automated High Throughput Screening Platform

Deadline : 06 Feb 2025

Other Information

Notice Type : Tender

TOT Ref.No.: 112766208

Document Ref. No. : IL-13845

Competition : ICB

Financier : Self Financed

Purchaser Ownership : Public

Tender Value : Refer Document

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Tender Details

Description

Opportunity:

Lawrence Livermore National Laboratory (LLNL), operated by the Lawrence Livermore National Security (LLNS), LLC under contract no. DE-AC52-07NA27344 (Contract 44) with the U.S. Department of Energy (DOE), is offering the opportunity to enter into a collaboration to further develop its automated high throughput screening platform.

Background:

Proteins, including antibodies, are increasingly becoming important as therapeutics. LLNL has developed an in silico antibody design platform based on AI tools. The approach requires experimental evaluation of in silico designed antibodies, which currently takes several weeks. There is a need to overcome this shortcoming and develop an automated and integrated platform that can accomplish this task rapidly.

Description:

LLNL inventors have developed a method and device for the high throughput screening of various chemical and biological entities using a novel combination of cell-free protein synthesis (in vitro transcription-translation), microencapsulation and optical interrogation. This includes automated sample handling, microemulsions, microfluidics manipulation, machine vision, and fluorescent interrogation. This automated system can be used to partition analytes into thousands of independent microdroplet reactions that are tracked and optically interrogated for assay activity. Since timing of droplet generation and position are known, an n-dimensional pooling strategy can be performed to increase screening throughput over the traditional 1:1 assay method. An optical interrogation method such as fluorescence correlation spectroscopy (FCS) can provide highly quantitative information for each reaction in real time (e.g., affinity constant for novel antibodies), significantly increasing the precision and quality of data that informs future models and experiments. The approach outlined will enable the feedback loop from experimental evaluations to occur in about 3 days rather ...
Active Contract Opportunity
Notice ID : IL-13845
Related Notice
Department/Ind. Agency : ENERGY, DEPARTMENT OF
Sub-tier : ENERGY, DEPARTMENT OF
Office: LLNS – DOE CONTRACTOR
General Information
Contract Opportunity Type: Special Notice (Original)
Original Published Date: Jan 06, 2025 02:24 pm PST
Original Response Date: Feb 06, 2025 03:00 pm PST
Inactive Policy: 15 days after response date
Original Inactive Date: Feb 21, 2025
Initiative:
Classification
Original Set Aside:
Product Service Code:
NAICS Code:
Place of Performance: Livermore, CA USA

Documents

 Tender Notice